GlaxoSmithKline, manufacturer of lamotrigine (Lamictal), the antiepileptic drug used widely for bipolar disorder, happily hid clinical trial results which found Lamictal was no better than a placebo. Given recent findings about how often pharmaceutical companies selectively push positive results to publication in medical journals while suppressing negative results, this can hardly be considered a surprise. It is nonetheless instructive to examine how the published data on Lamictal paint a much rosier picture of the drug’s efficacy compared to unpublished data….
….Ghaemi also did some digging on other drugs used for bipolar disorder and found that negative studies for Seroquel and Abilify were also lurking in the unpublished zone. However, it appears that Lamictal is the worst offender of the bunch. Is it just me, or is anyone else getting flashbacks to GSK’s handling of suicide data regarding its antidepressant Paxil? (read the rest of the post here)
I’ve known this in my gut for years. And as CL Psych writes the medical journals were calling it old news too, but who actually knew?? Not prescribing physicians.
The tragedy for me and so many of us coming off Lamictal? The withdrawal can be DEVASTATING. Click on that link to see the hundreds of comments left by people suffering withdrawal from this med that DOES NOT DO what it is purported to do!
The post on lamictal withdrawal gets more hits than any post on this entire site. It’s old and buried in the archives yet hundreds of people a week are googling “Lamictal Withdrawal” and finding my post. Why are they googling that?? It doesn’t take much to figure out most of them are having problems getting off lamictal.
Nasty withdrawals from a drug that does not even stabilize mood more often than placebo. Think long and hard people. Because most people in withdrawal face gross instability among other sometimes debilitating symtoms. This is a case of the drug, in withdrawal, causing the problem it’s supposed to treat while it most likely never did in the first place.
**note: this article is about Lamictal when used for “mood-disorders,” not epilepsy. Someone found this via google and found it confusing.
Much more info: Lamictal Redux