Protracted withdrawal from SSRIs and SNRIs antidepressants

Antidepressant withdrawal syndrome itself has nothing to do with the mythical imbalance of serotonin, norepinephrine, and dopamine that antidepressants are supposed to treat. It is autonomic damage: Disinhibition of the locus coeruleus and the glutamatergic system, which develops in the context of serotonin receptor downregulation, a recognized consequence of antidepressant use. For some people, it takes a long time for the serotonin receptors to correct. Without adequate serotonergic participation, other systems take over and establish a dysfunctional homeostasis.

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