Yes apparently it is absorbed into and changes DNA!! How delightful.
The abstract from this PDF file containing the study from The Journal of Biomolecular Structure and Dynamics is here:
Alprazolam Intercalates into DNA (p. 421-430)
In vitro interaction of a benzodiazepine group of drugs Alprazolam (Alp), a hypnotic and tranquilizer, with DNA was studied by various methods. Absorption spectrophotometric study showed that Alp binds strongly with supercoiled pUC 19 DNA and the calculated binding constant is 8.245 × 103 M-1 in 10 mM Tris-Cl buffer, pH 7.4. Spectrofluorometric study showed that ethidium bromide induced DNA fluorescence intensity was reduced completely after addition of Alp. But Alp did not interfere with the interaction of Hoechst 33258, a DNA minor groove binder, with plasmid DNA. Circular dichroic spectroscopic study showed that with the gradual increase in Alp concentrations, both the positive and the negative peaks of DNA were gradually decreased and at higher concentrations of Alp (60 μM and 80 μM), the negative peaks became positive indicating the intercalation and the conformational change in the DNA. Binding of Alp with DNA increased the thermal stability of DNA by 6 °C with respect to the mock treated sample. Gel electrophoresis study of supercoiled pUC 19 DNA showed more compact structure as a result of Alp binding. Transmission electron microscopic observations also confirmed this compactness. Thus, our observations suggest the strong interaction of Alp with DNA, which may raise serious questions about the random uses of Alprazolam.
And again I’d like to suggest having not studied other benzodiazepines we can’t assume they don’t do the same thing.
I can’t even begin to imagine the possible horror stories of what this possibly implies as I know little about science, but anyone who knows anything about DNA knows this is exceedingly serious.